A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study

Autor: Camila Amato Montalbano, Victor Nobrega, Cibele Orge, Bruno B. Andrade, Paula M Casais, Lais Cambui, Rivaldo Venâncio da Cunha, Viviane Boaventura, Laise de Moraes, Kevan Akrami, Aldina Barral, Thiago Cerqueira-Silva, Maria Jania Teixeira, Rita de Cássia Pontello Rampazzo, Manoel Barral-Netto, Luciane Amorim Santos, Karen Soares Trinta, Marco Aurélio Krieger, Ricardo Khouri, Luciano Pamplona Cavalcante
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
RNA viruses
Male
Viral Diseases
RC955-962
Social Sciences
Fevers
Blood Pressure
medicine.disease_cause
Pathology and Laboratory Medicine
Vascular Medicine
Cohort Studies
0302 clinical medicine
Risk Factors
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Medicine
Edema
Psychology
Chikungunya
Chikungunya Virus
virus diseases
Middle Aged
Arthralgia
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Hypertension
Sensory Perception
Female
Public aspects of medicine
RA1-1270
Pathogens
Cohort study
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Scoring system
Alphaviruses
030231 tropical medicine
Pain
Microbiology
Togaviruses
03 medical and health sciences
Young Adult
Signs and Symptoms
Diagnostic Medicine
Pain Management
Humans
Microbial Pathogens
Biology and life sciences
business.industry
Pruritus
Public Health
Environmental and Occupational Health
Organisms
Chikungunya Infection
Reproducibility of Results
Myalgia
Tropical Diseases
030104 developmental biology
Family medicine
Chikungunya Fever
business
Neuroscience
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008467 (2020)
ISSN: 1935-2735
1935-2727
Popis: Background Chikungunya virus (CHIKV) has caused worldwide epidemics that impose a major burden on health systems. Approximately half of infected individuals develop chronic debilitating arthralgia, affecting their quality of life. Here, we identified the relevant clinical and demographic variables in the acute phase of CHIKV infection prospectively linked to chronic arthralgia to elaborate a prognostic scoring system. Methods Acute CHIKV infection cases (n = 134) confirmed by serology or molecular test were examined
Author summary Debilitating articular pain frequently occurs as a consequence of Chikungunya virus infection, affecting individuals' quality of life for a long time. Here we present a simple tool to predict people at risk to remain with long-term articular pain after Chikungunya infection. We evaluated 134 patients acutely affected by Chikungunya virus searching for characteristics previously described as related to persistent symptoms. We examined about 80% of those individuals after one year to identify those with persistent arthralgia. We detected five features that represent good predictors and developed a scoring system named SHERA (www.sheracalculator.com/shera), the acronyms of Sex (female), Hypertension, Edema, Retroocular pain and Age (>26y). SHERA can correctly predict 8 out of every 10 Chikungunya infected individuals that will persist with articular pain symptoms at least one year after disease onset. These results were confirmed in the second group of patients from another city affected by Chikungunya outbreak. The easy-to-use scoring system can be applied in areas with limited access to health support, helping to identify the ones who will need special care and benefit from early intervention.
Databáze: OpenAIRE
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