Acute Drug-Induced Hepatitis Caused by Albendazole
| Autor: | An Na Kim, Gi Young Choi, Dong Wook Kang, Woong Chul Lee, Soung Hoon Cho, Sung Hee Jung, Hyeon Woong Yang, Yun Jung Lee, Hoon Go, Sang Woo Cha |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Alcoholic liver disease Antiprotozoal Agents Case Report Autoimmune hepatitis Albendazole Gastroenterology Necrosis Liver Function Tests Parasitex Drug-induced Internal medicine medicine Humans Hepatitis medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Eosinophils Glucose Liver Liver biopsy Immunology Abnormal Liver Function Test Hepatitis Toxic Chemical and Drug Induced Liver Injury business Liver function tests Viral hepatitis medicine.drug |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1011-8934 |
| DOI: | 10.3346/jkms.2008.23.5.903 |
| Popis: | Albendazole binds to parasite's tubulin inhibiting its glucose absorption. Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus. Although mainly metabolized in the liver, abnormal liver function tests were a rare adverse effect during clinical trials and we found no literature about albendazole-induced hepatitis requiring admission. This patient had a previous history of albendazole ingestion in 2002 resulting in increase of liver function tests. And in 2005, the episode repeated. We evaluated the patient for viral hepatitis, alcoholic liver disease, and autoimmune hepatitis, but no other cause of hepatic injury could be found. Liver biopsy showed periportal steatosis and periportal necrosis. The initial abnormal liver function test improved only with supportive care. These findings and the Roussel Uclaf Causality Assessment Method of the Council for International Organizations of Medical Sciences (RUCAM/CIOMS) score of 9 are compatible with drug-induced hepatitis so we report the case of this patient with a review of the literature. |
| Databáze: | OpenAIRE |
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