Vitamin D and neurocognitive dysfunction: Preventing 'D'ecline?
| Autor: | Bess Dawson-Hughes, Jennifer S. Buell |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry chemistry.chemical_element Calcium Biology Biochemistry Calcitriol receptor Neuroprotection Article Internal medicine medicine Vitamin D and neurology Animals Humans Dementia Vitamin D Receptor Molecular Biology Calcium metabolism Brain General Medicine medicine.disease Endocrinology chemistry Receptors Calcitriol Molecular Medicine Nervous System Diseases Cognition Disorders Neurocognitive |
| Zdroj: | Molecular Aspects of Medicine. 29:415-422 |
| ISSN: | 0098-2997 |
| DOI: | 10.1016/j.mam.2008.05.001 |
| Popis: | A preponderance of evidence supports a role for vitamin D beyond the classical function in mineral homeostasis. Epidemiologic investigations have revealed a beneficial role of vitamin D in muscle function, cardiovascular health, diabetes, and cancer prevention. More recently, studies have suggested a potential beneficial role of vitamin D in cognitive function. Vitamin D exhibits functional attributes that may prove neuroprotective through antioxidative mechanisms, neuronal calcium regulation, immunomodulation, enhanced nerve conduction and detoxification mechanisms. Compelling evidence supports a beneficial role for the active form of vitamin D in the developing brain as well as in adult brain function. The vitamin D receptor and biosynthetic and degradative pathways for the hydroxylation of vitamin D have been found in the rodent brain; more recently these findings have been confirmed in humans. The vitamin D receptor and catalytic enzymes are colocalized in the areas of the brain involved in complex planning, processing, and the formation of new memories. These findings potentially implicate vitamin D in neurocognitive function. |
| Databáze: | OpenAIRE |
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