Early elevation of serum tumor necrosis factor-α is associated with poor outcome in subarachnoid hemorrhage
| Autor: | MingMing Ning, Christopher S. Ogilvy, Sherry H.-Y. Chou, Philip L. De Jager, Rachael G. Konigsberg, Steven K. Feske, Juli Atherton, Rose Du, Eng H. Lo |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Subarachnoid hemorrhage Inflammation General Biochemistry Genetics and Molecular Biology Article Internal medicine medicine Humans cardiovascular diseases Interleukin 6 medicine.diagnostic_test biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Vasospasm General Medicine Middle Aged Subarachnoid Hemorrhage medicine.disease Prognosis nervous system diseases Anesthesia Cohort Angiography Cardiology biology.protein Biomarker (medicine) Tumor necrosis factor alpha Female medicine.symptom business |
| Zdroj: | Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 60(7) |
| ISSN: | 1708-8267 |
| Popis: | Objective Subarachnoid hemorrhage (SAH) is associated with inflammation that may mediate poor outcome in SAH. We hypothesize that elevated serum tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) are associated with vasospasm and poor outcome in SAH. Methods In 52 consecutive SAH subjects, we compared TNF-α and IL-6 levels on post-SAH days 0 to 1, 2 to 3, 4 to 5, 6 to 8, and 10 to 14 with respect to vasospasm and to poor outcome at 3 and 6 months. Vasospasm was defined as more than 50% reduction in vessel caliber on angiography. Poor outcome was defined as modified Rankin score greater than 2. Results Elevated TNF-α on post-SAH days 2 to 3 was associated with poor 3-month outcome ( P = 0.0004). Global elevation of TNF-α over time (post-SAH days 0–14) was independently associated with poor 3-month outcome after adjusting for Hunt-and-Hess grade and age ( P = 0.02). Neither cross-sectional nor IL-6 levels over time were associated with outcome. Neither TNF-α nor IL-6 levels were associated with vasospasm. Conclusions Elevation in serum TNF-α on post-SAH days 2 to 3 and global elevation of TNF-α over time are associated with poor outcome but not with angiographic vasospasm in this small cohort. Future studies are needed to define the role of TNF-α in SAH-related brain injury and its potential as a SAH outcome biomarker. |
| Databáze: | OpenAIRE |
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