Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians
| Autor: | Mark Seielstad, Sangkot Marzuki, Ron Nelwan, Eileen Png, Bachti Alisjahbana, Reinout van Crevel, Martin L. Hibberd, Esther van de Vosse, Edhyana Sahiratmadja, Iskandar Adnan, Tom H. M. Ottenhoff |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Tuberculosis Genotype Genome-wide association study Single-nucleotide polymorphism Polymorphism Single Nucleotide Microbiology SP110 Cohort Studies Minor Histocompatibility Antigens Mycobacterium tuberculosis Pulmonary tuberculosis medicine Genetics Humans SNP Genetic Predisposition to Disease Tuberculosis Pulmonary Molecular Biology Ecology Evolution Behavior and Systematics Chi-Square Distribution biology Poverty-related infectious diseases [N4i 3] Nuclear Proteins Case-control biology.organism_classification medicine.disease Infectious Diseases Susceptibility Indonesia Case-Control Studies Cohort Immunology Infection severity Poverty-related infectious diseases Infectious diseases and international health [N4i 3] |
| Zdroj: | Infection, Genetics and Evolution, 12, 1319-23 Infection, Genetics and Evolution, 12, 6, pp. 1319-23 |
| ISSN: | 1567-1348 |
| Popis: | Item does not contain fulltext Despite being high transmissible, Mycobacterium tuberculosis (M. tuberculosis) infection causes active disease in only 5-10% of disease-susceptible individuals. This has instigated interest in studying potentially underlying genetic host factors and mechanisms in tuberculosis (TB). The recent identification of the Intracellular pathogen resistance 1 (Ipr1) gene, which plays a major role in controlling M. tuberculosis susceptibility and infection severity in mice (Pan et al., 2005), has prompted studies on its human homolog; SP110 in humans. Association of SP110 SNPs with pulmonary TB were first reported in a study on West African families (Tosh et al., 2006). Subsequent attempts to replicate these findings in other populations, including another West African (Ghanaian) cohort (Thye et al., 2006), however, were unsuccessful. Here we have genotyped 20 SNPs located in the SP110 gene, including the previously TB associated variants; rs2114592 and rs3948464, for the first time in a South East Asian cohort from Indonesia. Our study did not reveal any statistically significant associations between SP110 SNPs and pulmonary TB. In addition, a meta-analysis of the two previously TB associated SNPs revealed that these are not associated with TB, further confirming the lack of convincing evidence for SP110 to be implicated in TB susceptibility, as yet in humans. 01 augustus 2012 |
| Databáze: | OpenAIRE |
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