Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China
| Autor: | Lunbiao Cui, Yiyue Ge, Wenshuai Zhang, Tao Wu, Fengcai Zhu, Bin Wu, Xiling Guo, Yongjun Jiao, Chao Huang, Ying Chi, Tian Wen, Jingxian Liu, Baoli Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A 0301 basic medicine Macrophage colony-stimulating factor Chemokine medicine.medical_treatment Pneumonia Viral Severity of Illness Index Asymptomatic Proinflammatory cytokine Betacoronavirus 03 medical and health sciences 0302 clinical medicine Granulocyte Colony-Stimulating Factor Severity of illness Major Article cytokine medicine Humans Immunology and Allergy AcademicSubjects/MED00860 Pandemics Chemokine CCL2 biology SARS-CoV-2 business.industry chemokine COVID-19 Middle Aged Viral Load Granulocyte colony-stimulating factor AcademicSubjects/MED00290 030104 developmental biology Infectious Diseases Cytokine 030220 oncology & carcinogenesis Immunology biology.protein Cytokines Female disease severity Chemokines medicine.symptom Coronavirus Infections business Viral load |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the serum cytokine and chemokine levels in asymptomatic, mild, moderate, severe, and convalescent SARS-CoV-2–infected cases. Proinflammatory cytokine and chemokine production induced by SARS-CoV-2 were observed not only in symptomatic patients but also in asymptomatic cases, and returned to normal after recovery. IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, MCP-1, MCP-3, IP-10, MIG, and MIP-1α were found to be associated with the severity of COVID-19. Moreover, a set of cytokine and chemokine profiles were significantly higher in SARS-CoV-2–infected male than female patients. The serum levels of MCP-1, G-CSF, and VEGF were weakly and positively correlated with viral titers. We suggest that combinatorial analysis of serum cytokines and chemokines with clinical classification may contribute to evaluation of the severity of COVID-19 and optimize the therapeutic strategies. The serum levels of IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, IP-10, MCP-1, MCP-3, MIG, and MIP-1α were associated with the severity of COVID-19. Men had higher levels of cytokines/chemokines than women. Some cytokines/chemokines were weakly correlated with the viral load. |
| Databáze: | OpenAIRE |
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