A Simple Contact Heat Experimental Pain Model for Evaluation of Analgesic Agents in Healthy Volunteers
| Autor: | Takallapalli Ramesh Kumar Rao, Madireddy Umamaheshwar Rao Naidu, Pingali Usha Rani, Sunil Kumar Reddy Khambam |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pharmacology
tramadol validation medicine.medical_specialty business.industry Clinical pain Analgesic Analgesic agents Surgery heat pain detection Healthy volunteers medicine Physical therapy Pharmacology (medical) contact heat Tramadol heat detection Heat detection Contact heat business reproducibility Original Research medicine.drug |
| Zdroj: | Current Therapeutic Research. (6):233-242 |
| ISSN: | 0011-393X |
| DOI: | 10.1016/j.curtheres.2011.11.001 |
| Popis: | BackgroundHuman experimental pain models help to understand the mechanism of the underlying clinical pain conditions and can be adopted to test analgesic efficacy of drugs used in the management of pain. In early phases, the clinical development of new analgesic agents is severely hindered due to lack of reliable sensitive tests for the experimental pain models.ObjectiveThe aim of the present study was to standardize and validate a simple contact heat pain model that can be used for future screening of various analgesic agents.MethodsThe method was standardized by recording heat detection and heat pain detection threshold in degrees centigrade in 24 healthy volunteers. Reproducibility of the test procedure was evaluated by recording the thermal threshold parameters by a single observer on 2 sessions (inter-day reproducibility) and a second observer on 1 session (inter-observer reproducibility) separately. Validity of model was further tested by evaluating the analgesic effect of tramadol on 12 healthy volunteers.ResultsThermal pain model using contact heat method was found to produce low variability with coefficient of variation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|