Prognostic Value of Lymph Node Density in Patients With T3 and T4 Pyriform Sinus Carcinoma
| Autor: | Ziyuan Zhou, Jingya Li, Lifeng Jia, Wei Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male squamous cell carcinoma Cancer Research Prognostic factor medicine.medical_specialty recurrence Kaplan-Meier Estimate lcsh:RC254-282 survival 03 medical and health sciences 0302 clinical medicine Humans Medicine In patient prognostic factor 030223 otorhinolaryngology Lymph node Aged Neoplasm Staging Hypopharyngeal Neoplasms Pyriform Sinus Carcinoma business.industry Patient survival Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens pyriform sinus Tumor recurrence Pyriform Sinus medicine.anatomical_structure ROC Curve Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Female Original Article Lymph Nodes Radiology Neoplasm Grading business |
| Zdroj: | Technology in Cancer Research & Treatment Technology in Cancer Research & Treatment, Vol 19 (2020) |
| ISSN: | 1533-0338 1533-0346 |
| DOI: | 10.1177/1533033820945806 |
| Popis: | Background/Aim: Lymph node density is a parameter used to more accurately predict tumor recurrence and patient survival. However, its association with surgical outcome in pyriform sinus carcinoma remains unclear. The purpose of this study was to assess the prognostic value of lymph node density in advanced pyriform sinus carcinoma. Patients and Methods: A total of 87 patients with pyriform sinus carcinoma treated between 2008 and 2015 were enrolled. Then, 5-year overall survival, 5-year disease-specific survival, 5-year disease-free survival, and 5-year regional recurrence-free survival were utilized to assess the prognostic significance of lymph node density. Results: With a median follow-up period of 31.8 months, 5-year overall survival, disease-specific survival, disease-free survival, and regional recurrence-free survival were 37.9%, 46.0%, 41.4%, and 54.0%, respectively. Univariate analysis revealed that lymph node density ≥ 0.093 was a significant predictor of poor 5-year overall survival ( P = .005), disease-specific survival ( P = .008), disease-free survival ( P = .0013), and regional recurrence-free survival ( P = .003). Furthermore, multivariate analysis demonstrated that lymph node density was negatively associated with adverse 5-year overall survival (hazard ratio = 1.62, 95% CI: 1.15-2.29, P = .006), disease-specific survival (hazard ratio = 1.86, 95% CI: 1.24-2.80, P = .003), disease-free survival (hazard ratio = 0.45, 95% CI: 0.24-0.85, P = .014), and regional recurrence-free survival (hazard ratio = 2.97, 95% CI: 1.43-6.17, P = .004). Conclusion: Taken together, these results reveal that lymph node density is a powerful prognostic factor for patients with T3 and T4 pyriform sinus carcinoma, and the median lymph node density cutoff values ≥ 0.093 are associated with a greater risk of recurrence and poorer survival. |
| Databáze: | OpenAIRE |
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