Spatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb

Autor: Ganesh Vasan, Keeley L. Baker, Justus V. Verhagen, Ankita Gumaste, Vincent A. Pieribone
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Nasal cavity
Physiology
Respiratory System
Mechanotransduction
Cellular
Brain mapping
Epithelium
0302 clinical medicine
Medicine and Health Sciences
Biology (General)
Materials
Spatial organization
Flow Rate
Brain Mapping
Physics
Respiration
General Neuroscience
Brain
Classical Mechanics
Olfactory Bulb
Dynamics
Smell
medicine.anatomical_structure
Inhalation
Breathing
Air Flow
Physical Sciences
Female
Mechanosensitive channels
Anatomy
Nasal Cavity
General Agricultural and Biological Sciences
Research Article
QH301-705.5
Materials Science
Mice
Transgenic
Fluid Mechanics
Biology
Continuum Mechanics
General Biochemistry
Genetics and Molecular Biology
Aerodynamics
03 medical and health sciences
medicine
Animals
General Immunology and Microbiology
Biology and Life Sciences
Fluid Dynamics
Olfactory Perception
Sensory neuron
Olfactory bulb
Bulb
Biological Tissue
030104 developmental biology
Odor
Odorants
Physiological Processes
Neuroscience
030217 neurology & neurosurgery
Zdroj: PLoS Biology, Vol 17, Iss 9, p e3000409 (2019)
PLoS Biology
ISSN: 1545-7885
1544-9173
Popis: The mammalian olfactory bulb (OB) plays an essential role in odor processing during the perception of smell. Optical imaging of the OB has proven to be a key tool in elucidating the spatial odor mapping and temporal dynamics that underlie higher-order odor processing. Much is known about the activation of olfactory sensory neuron (OSN) glomerular responses in the dorsal olfactory bulb (dOB) during odor presentation. However, the dorsal bulb provides access to only approximately 25% of all glomeruli, and little is known about how the lateral bulb functions during this critical process. Here, we report, for the first time, simultaneous measurements of OSN glomerular activity from both the dOB and the lateral olfactory bulb (lOB), thus describing odor-specific spatial mapping and the temporal dynamics of olfactory input to both the dorsal and lateral bulb. Odor responses in the lateral bulb tended to be most prominent in the dorso-lateral (D-L) region. Lateral glomeruli became active in a dorso-ventral (D-V) sequence upon odor inhalation, unlike the anterio-posterior (A-P) activity wave typical of the dorsal glomeruli. Across the entire D-L bulb, the spatial organization of these dynamics can be explained neither by the purely mechanosensitive dynamics (to breathing clean air) nor by the response amplitudes across glomeruli. Instead, these dynamics can be explained by a combination of zonal receptor distributions, associated OB projections, and air flow paths across the epithelium upon inhalation. Remarkably, we also found that a subset of OSN glomeruli in the lOB was highly sensitive to extranasal air pressure changes, a response type that has not been reported in dorsal glomeruli.
The mammalian olfactory bulb plays an essential role in odor processing during the perception of smell, but most studies have focused on the dorsal olfactory bulb, which contains only a quarter of all glomeruli. In this study, imaging of the lateral olfactory bulb reveals new properties in smell processing.
Databáze: OpenAIRE
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