Release of ciprofloxacin drugs by nano gold embedded cellulose grafted polyacrylamide hybrid nanocomposite hydrogels

Autor: Kalyani Prusty, Sarat K. Swain
Rok vydání: 2019
Předmět:
Materials science
Polyacrylamide
Acrylic Resins
Metal Nanoparticles
macromolecular substances
02 engineering and technology
Biochemistry
Cell Line
Nanocomposites
Mice
03 medical and health sciences
chemistry.chemical_compound
X-Ray Diffraction
Ciprofloxacin
Structural Biology
Spectroscopy
Fourier Transform Infrared
Animals
Thermal stability
Fourier transform infrared spectroscopy
In situ polymerization
Cellulose
Molecular Biology
030304 developmental biology
0303 health sciences
Nanocomposite
Cell Death
Photoelectron Spectroscopy
Temperature
technology
industry
and agriculture
Hydrogels
General Medicine
Fibroblasts
021001 nanoscience & nanotechnology
Thermogravimetry
Drug Liberation
Chemical engineering
chemistry
Transmission electron microscopy
Colloidal gold
Gold
Rheology
0210 nano-technology
Zdroj: International Journal of Biological Macromolecules. 126:765-775
ISSN: 0141-8130
Popis: The present work involves the designing of the porous nano gold embedded cellulose grafted polyacrylamide (PAM/C/Au) nanocomposite hydrogel which has been prepared by in situ polymerization process with an objective of application for the in vitro release of ciprofloxacin drugs. The structure, composition, morphology behaviour of the nanocomposite hydrogels are explored using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction study (XRD), X-ray photoelectron spectroscopy (XPS); field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The thermal stability of the as synthesized nanocomposite hydrogels are studied by TGA. The gelling actions of prepared nanocomposite hydrogels are determined by the rheological study. The investigations of cytotoxicity tests and antibacterial behaviour along with negative and positive actions of nanocomposite hydrogels are investigated. The study of the release rate of ciprofloxacin drugs is carried out by measuring water retention and swelling properties of nanocomposite hydrogels. The in vitro release rate of ciprofloxacin antibiotic drug is found to be 96.6% in 5 h. The PAM/C/Au nanocomposite hydrogels with improved thermal and rheological properties are suitable proposed as a good carrier towards in vitro release of the ciprofloxacin drugs.
Databáze: OpenAIRE
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