Discharge Use of Carvedilol Is Associated With Higher Survival in Japanese Elderly Patients With Heart Failure Regardless of Left Ventricular Ejection Fraction
| Autor: | Katsunori Ishida, Masayuki Hirai, Kiyotaka Yanagihara, Shinobu Sugihara, Kensaku Yamada, Kazuhiro Yamamoto, Masahiko Kato, Yoshiharu Kinugasa |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic beta-Antagonists Carbazoles Ventricular Function Left Cohort Studies Propanolamines Pulmonary Disease Chronic Obstructive Ventricular Dysfunction Left Japan Internal medicine Humans Medicine Carvedilol Survival rate Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Heart Failure Pharmacology Ejection fraction business.industry Proportional hazards model Age Factors Retrospective cohort study medicine.disease Patient Discharge humanities Survival Rate Clinical trial Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies Cohort study medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 62:485-490 |
| ISSN: | 0160-2446 |
| Popis: | Previous clinical trials have proven beneficial effects of beta-blockers in patients with heart failure (HF) with reduced ejection fraction (EF). However, those studies excluded elderly patients from the subjects or included only a small number of them. We assessed whether beta-blocker treatment with carvedilol improves survival in elderly patients with HF regardless of left ventricular EF (LVEF). We retrospectively analyzed a total of 189 patients older than 75 years who were hospitalized with HF from January 2004 to December 2010. Of these, 84 patients (44%) had been treated with carvedilol at discharge. Patients treated with carvedilol were younger, were less likely to have chronic obstructive pulmonary disease, and had lower LVEF compared with those without carvedilol (all P0.05). During the median follow-up of 2.5 years after discharge, 92 patients died. Cox hazard analysis showed that, even after adjustment for covariates, carvedilol significantly decreased all-cause mortality in this cohort (P0.01). Furthermore, a beneficial effect on outcome was found in patients with reduced (LVEF ≤ 40%) and preserved (LVEF40%) EF (all P0.05). In conclusion, Beta-blockers may provide beneficial effects on Japanese elderly patients with HF regardless of LVEF. |
| Databáze: | OpenAIRE |
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