A 25-Year Study of the Clinical and Histologic Outcomes of Hepatitis C Virus Infection and Its Modes of Transmission in a Cohort of Initially Asymptomatic Blood Donors
| Autor: | Cathy Conry-Cantilena, Cathy Schechterly, Joan Gibble, Marc G. Ghany, Paul M. Ness, David E. Kleiner, Harvey J. Alter, Deloris E. Koziol, Robert D. Allison |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Blood transfusion Cirrhosis Biopsy Hepatitis C virus medicine.medical_treatment Immunoblotting Blood Donors Hepacivirus Antibodies Viral medicine.disease_cause Gastroenterology Asymptomatic Cohort Studies Major Articles and Brief Reports Risk Factors Internal medicine medicine Humans Immunology and Allergy medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction business.industry Hepatitis C Odds ratio Hepatitis C Chronic medicine.disease Logistic Models Infectious Diseases Liver biopsy Multivariate Analysis RNA Viral Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Infectious Diseases. 206:654-661 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jis410 |
| Popis: | Background.A total of 738 volunteer blood donors who were positive for anti–hepatitis C virus (HCV) were assessed for risk factors and outcomes for up to 15 years within the study and up to 54 years from the estimated onset of infection. Methods.A third-generation recombinant immunoblot assay (RIBA) was performed to distinguish true from false anti-HCV reactivity. Findings of HCV polymerase chain reaction classified subjects as having chronic HCV infection or as having recovered. Liver biopsy specimens were staged by Ishak fibrosis score and graded by histologic activity index. Results.Of 738 anti-HCV–positive subjects, 469 (64%) had positive RIBA results, 217 (29%) had negative results, and 52 (7%) had indeterminate results. Primary independent risk factors were injection drug use (odds ratio [OR], 35.0; P |
| Databáze: | OpenAIRE |
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