Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors

Autor:	Darrin Stuart, Teresa E. Williams, Daniel Poon, Savithri Ramurthy, Payman Amiri, Sharadha Subramanian, Cynthia M. Shafer, Abran Costales, Barry Levine, Joelle Verhagen, Paul A. Renhowe, Christopher McBride
Rok vydání:	2014
Předmět:	MAPK/ERK pathway Benzimidazole biology Organic Chemistry MAPK7 Biochemistry MAP2K7 chemistry.chemical_compound chemistry In vivo Mitogen-activated protein kinase Drug Discovery biology.protein c-Raf Tyrosine kinase
Zdroj:	ACS medicinal chemistry letters. 5(9)
ISSN:	1948-5875
Popis:	Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631da30643ffa236aa0d6a9d30aec126 https://pubmed.ncbi.nlm.nih.gov/25514817 Zobrazit plný text záznamu