Effect of Cortisone on Experimental Fractures in the Rabbit

Autor:	Karl Meyer, Edward L. Howes, Blunt Jw, Charles Ragan, Lattes R, Charles M. Plotz
Rok vydání:	1950
Předmět:	medicine.medical_specialty business.industry Connective tissue medicine.disease General Biochemistry Genetics and Molecular Biology Surgery Cortisone Fractures Bone Hematoma medicine.anatomical_structure Treated animal medicine Animals Femur Blood supply Rabbits business medicine.drug
Zdroj:	Experimental Biology and Medicine. 73:678-681
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-73-17785
Popis:	Summary1. Sixteen rabbits were subjected to fractures of the femur. Eight of these were under treatment with cortisone.2. One control and one treated animal were sacrificed serially for eight days following fracture.3. Gross healing of the fracture and absorption of the hematoma were greatly delayed in the animals receiving cortisone.4. Histologically, the chief differences were seen following the fourth post-fracture day when retardation of all phases of healing were noted in the cortisone-treated animals. At the fourth day, new blood vessels began to appear in both control and cortisone-treated rabbits, but were more numerous in the control animals.5. Failure of connective tissue regeneration following the fourth post-fracture day in the cortisone-treated rabbits may have been the result of poor tissue nutrition due to an inadequate blood supply or may have been due to the action of a circulating material possibly cortisone itself, brought to the area through new vessels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631c0505158a2db0c164c3fdcc6965d8 https://doi.org/10.3181/00379727-73-17785 Zobrazit plný text záznamu