The relationship between acute exacerbation of chronic obstructive pulmonary disease and neutrophile-to-lymphocyte ratio, serum uric acid and gamma-glutamyl transferase levels
| Autor: | Nalan Ogan, Sezen Bağlan Uzunget, Berkay Ekici |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Gynecology
medicine.medical_specialty inflammation C- reactive protein Chronic obstructive pulmonary disease neutrophil/lymphocyte ratio serum uric acid business.industry Health Care Sciences and Services Medicine kronik obstriktif akciğer hastalığı nötrofil lenfosit oranı inflamasyon C reaktif protein serum ürik asit inflamasyon Sağlık Bilimleri ve Hizmetleri business |
| Zdroj: | Volume: 8, Issue: 3 105-112 Turkish Journal of Clinics and Laboratory |
| ISSN: | 2149-8296 |
| Popis: | Amaç: Kronik inflamasyon,kronik obstrüktif akciğer hastalığında (KOAH) patojenik bir rol oynamaktadır.Dolaşımdaki nötrofil-lenfosit oranı (N / L oranı), serum ürik asit vegama-glutamil transferaz (GGT) düzeylerindeki artış, sistemik bir iltihabıngöstergesi olabilir.Bu çalışmanın amaı KOAH'lı hastalarda biyolojik belirteç olarak kannötrofil-lenfosit (N / L) oranı ile serum ürik asit ve gama-glutamil transferaz(GGT) düzeylerinin muhtemel rolü üzerindeki olası değerini değerlendirmektir.Gereç ve Yöntemler: Retrospektif birçalışma.Gereç ve Yöntem: Örneklem, KOAH'ın stabil ve akut alevlenmesi içingöğüs hastalıkları bölümümüze başvuran 260 hastadan (stabil KOAH, n = 68,KOAH'ın akut alevlenişi, n = 192) oluşturuldu.Bulgular: KOAH hastalarının akutalevlenmesinde yüksek N / L oranları ve serum ürik asit seviyeleri tespitedildi (p Aim: Chronic inflammationplays a pathogenic role in chronic obstructive pulmonary disease. Increase in the ratio of circulating neutrophil tolymphocyte ratio (NLR), serum uric acid and gamma-glutamyl transferase (GGT) levels may serve as a marker of systemicinflammation. The aim of this study is to evaluate the potential predictivevalue of blood neutrophil-to- lymphocyte NLR and possible role of serum uricacid and gamma-glutamyl transferase levels as biomarkers in chronic obstructivepulmonary disease patients.Material and Methods: The sample was derived from a populationof 276 patients admitted for acute exacerbation of chronic obstructivepulmonary disease to our respiratory medicine department.Results: Higher N/L ratios,uric acid and GGT levels were detected in chronic obstructive pulmonary diseasepatients than in the controls (P < 0.001). Positive correlations betweensmoking (pack-years) and NLR, serum GGT, uric acid, and C- reactive proteinlevels were found (P < 0.001; r = 0.339, P < 0.001; r = 0.224, P < 0.001;r= 0.242,and P < 0.001; r = 0.563, respectively).Conclusion: Our study demonstratedthat NLR, serum GGT and uric acid levels are significantly higher in patientswith chronic obstructive pulmonarydisease. With regard to the associations between chronic obstructive pulmonarydisease and these parameters, they can be used to determine disease burdenbesides other risk factors in routine clinical practice. |
| Databáze: | OpenAIRE |
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