Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease

Autor: Albert D. Windhorst, Bart N.M. van Berckel, Emma M. Coomans, Denise Visser, Rik Ossenkoppele, Wiesje M. van der Flier, Sander C.J. Verfaillie, Juhan Reimand, Tessa Timmers, Philip Scheltens, Ronald Boellaard, Emma E. Wolters, Hayel Tuncel
Přispěvatelé: Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Neurology, ACS - Heart failure & arrhythmias, APH - Personalized Medicine, APH - Methodology
Rok vydání: 2020
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 47(13), 3165-3175. Springer Verlag
Visser, D, Wolters, E E, Verfaillie, S C J, Coomans, E M, Timmers, T, Tuncel, H, Reimand, J, Boellaard, R, Windhorst, A D, Scheltens, P, van der Flier, W M, Ossenkoppele, R & van Berckel, B N M 2020, ' Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 13, pp. 3165-3175 . https://doi.org/10.1007/s00259-020-04831-w
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-020-04831-w
Popis: Purpose We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer’s disease (AD), by using a single dynamic [18F]flortaucipir positron emission tomography (PET) scan. Methods Seventy-one subjects with AD (66 ± 8 years, mini-mental state examination (MMSE) 23 ± 4) underwent a dynamic 130-min [18F]flortaucipir PET scan. Cognitive assessment consisted of composite scores of four cognitive domains. For tau pathology and rCBF, receptor parametric mapping (cerebellar gray matter reference region) was used to create uncorrected and partial volume-corrected parametric images of non-displaceable binding potential (BPND) and R1, respectively. (Voxel-wise) linear regressions were used to investigate associations between BPND and/or R1 and cognition. Results Higher [18F]flortaucipir BPND was associated with lower R1 in the lateral temporal, parietal and occipital regions. Higher medial temporal BPND was associated with worse memory, and higher lateral temporal BPND with worse executive functioning and language. Higher parietal BPND was associated with worse executive functioning, language and attention, and higher occipital BPND with lower cognitive scores across all domains. Higher frontal BPND was associated with worse executive function and attention. For [18F]flortaucipir R1, lower values in the lateral temporal and parietal ROIs were associated with worse executive functioning, language and attention, and lower occipital R1 with lower language and attention scores. When [18F]flortaucipir BPND and R1 were modelled simultaneously, associations between lower R1 in the lateral temporal ROI and worse attention remained, as well as for lower parietal R1 and worse executive functioning and attention. Conclusion Tau pathology was associated with locally reduced rCBF. Tau pathology and low rCBF were both independently associated with worse cognitive performance. For tau pathology, these associations spanned widespread neocortex, while for rCBF, independent associations were restricted to lateral temporal and parietal regions and the executive functioning and attention domains. These findings indicate that each biomarker may independently contribute to cognitive impairment in AD.
Databáze: OpenAIRE
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