Changes in Gastric Mucosal Cell Proliferation after Antrectomy or Vagotomy in Man
| Autor: | Lars Bo Svendsen, J K Larsen, Hansen Oh |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Duodenum medicine.medical_treatment Cell Vagotomy Gastroenterology Gastrectomy Internal medicine Pyloric Antrum medicine Gastric mucosa Humans Stomach Ulcer Intestinal Mucosa Progenitor cell Antrum Aged Gastrin business.industry Epithelial Cells Middle Aged digestive system diseases medicine.anatomical_structure Gastric Mucosa Duodenal Ulcer Gastritis Autoradiography Female Atrophy medicine.symptom business Cell Division |
| Zdroj: | Scandinavian Journal of Gastroenterology. 13:947-952 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365527809181374 |
| Popis: | The rate of gastric epithelial cell proliferation was studied in peptic ulcer patients treated by partial gastrectomy or proximal gastric vagotomy (PGV). Endoscopic biopsies were incubated in vitro with 3H-thymidine and autoradiographs were prepared. The percentage of DNA-synthesizing cells (labeling index) in the progenitor cell region was estimated. Five patients were studied before and 3 months after antrectomy, whereas six other subjects were studied before and 2 weeks and 2 months after PGV. The results indicate that epithelial cell proliferation in fundic mucosa is accelerated after antrectomy in man and that PGV is followed by an increased rate of cell renewal in fundic and antral mucosa, whereas the kinetic parameters in duodenal mucosa remain unaffected by this operation. It is concluded that the proliferative changes after these operations are most likely caused by the development of gastritis. The study did not support the hypothesis that gastrin exerts a physiological trophic action on human gastric mucosa. |
| Databáze: | OpenAIRE |
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