Effect of direct hemoperfusion with a polymyxin B immobilized fiber column on high mobility group box-1 (HMGB-1) in severe septic shock: report of a case
| Autor: | Yuichiro Sakamoto, Kenkichi Takei, Yoshiaki Hara, Yoshiteru Tomita, Yasuhiro Yamamoto, Noriyosho Kutsukata, Kunihiro Mashiko, Hisashi Matsumoto, Yukihiro Ueno |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering Polymyxin b immobilized fiber Gastroenterology Severity of Illness Index Biomaterials Sepsis Internal medicine Severity of illness medicine Humans HMGB1 Protein Polymyxin B Aged 80 and over business.industry Septic shock Interleukin-6 General Medicine medicine.disease Hemoperfusion Shock Septic Surgery Blockade Anti-Bacterial Agents Endotoxins Shock (circulatory) Female medicine.symptom business Tomography X-Ray Computed Intestinal Obstruction medicine.drug |
| Zdroj: | ASAIO journal (American Society for Artificial Internal Organs : 1992). 52(6) |
| ISSN: | 1538-943X |
| Popis: | Because of the many difficult aspects in the treatment of septic shock and poor outcome of this condition, establishing the most appropriate therapeutic strategy is problematic. Recently, high mobility group box-1 (HMGB-1) has been shown to activate inflammatory responses and to be a late mediator in endotoxemia and sepsis. Therefore, we considered that it might be worthwhile to investigate the therapeutic potential of HMGB-1 blockade in cases of septic shock.Herein, we describe the case of a patient with septic shock with hepatic portal venous gas caused by intestinal obstruction. Hepatic portal venous gas is a rare condition associated with significant radiographic findings and a fatal outcome. Our patient, however, recovered from severe septic shock and was saved by the use of direct hemoperfusion with a polymyxin B immobilized fiber column (DHP-PMX). This treatment resulted in a decrease in the serum levels of endotoxin, interleukin-6 (IL-6), and HMGB-1. |
| Databáze: | OpenAIRE |
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