Laryngeal and Esophageal Mucosal Protection Using the Angico Gum Biopolymer in a Mouse Model of Reflux

Autor: Thiago Meneses Araújo Leite Sales, Renata Rocha do Nascimento, João Pedro do Carmo Neto, Humberto Barbosa da Costa Filho, Suliana Mesquita Paula, Maria Klayre Araújo de Sousa, Kerolayne de Melo Nogueira, Genílson José Dias Junior, Durcilene Alves da Silva, Pedro Marcos Gomes Soares, Jand Venes Rolim Medeiros, Lucas Antonio Duarte Nicolau, Daniel Sifrim, Marcellus Henrique Loiola Ponte de Souza
Rok vydání: 2022
Předmět:
Zdroj: The Laryngoscope. 133:162-168
ISSN: 1531-4995
0023-852X
DOI: 10.1002/lary.30093
Popis: This study aimed to evaluate the in vivo protective effect of the angico gum biopolymer in reducing the inflammatory response and preserving the integrity of the laryngeal and esophageal mucosa.Animal study.A murine surgical model of gastroesophageal reflux disease was accomplished and subsequently treated with angico gum or omeprazole. On days 3 and 7 post surgery, samples of the larynx and esophagus, respectively, were collected to measure the level of inflammation (wet weight and myeloperoxidase activity) and mucosal integrity (transepithelial electrical resistance and mucosal permeability to fluorescein).Angico gum and omeprazole decreased laryngeal inflammation (wet weight and myeloperoxidase activity) and dramatically improved the integrity of the laryngeal mucosa. It also reduced inflammation (decreased wet weight and myeloperoxidase activity) of the esophagus and preserved the barrier function (inferred by assessing the integrity of the mucosa).This study demonstrates the protective effect of angico gum in an experimental gastroesophageal reflux disease model. Angico gum attenuates inflammation and impairment of the mucosal barrier function not only in the larynx but also in the esophagus.NA Laryngoscope, 133:162-168, 2023.
Databáze: OpenAIRE
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