Vasopressin SNP pain factors and stress in sickle cell disease
| Autor: | Marie L. Suarez, Robert E. Molokie, Zaijie Jim Wang, Yingwei Yao, Keesha L. Powell-Roach, Miriam O. Ezenwa, Diana J. Wilkie, Ying He, Ellie H. Jhun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Critical Care and Emergency Medicine Peptide Hormones Social Sciences Disease Biochemistry 0302 clinical medicine Acute care Genotype Outpatients Medicine and Health Sciences Medicine Psychology Ethnicities Stress measures Amino Acids African American people Multidisciplinary Organic Compounds Chronic pain Hematology Population groupings Middle Aged 3. Good health Chemistry Genetic Diseases 030220 oncology & carcinogenesis Physical Sciences Female Basic Amino Acids Vasopressin Research Article Adult medicine.medical_specialty Patients Vasopressins Science Psychological Stress Pain Single-nucleotide polymorphism Anemia Sickle Cell Arginine Polymorphism Single Nucleotide Molecular Genetics 03 medical and health sciences Young Adult Autosomal Recessive Diseases Internal medicine Mental Health and Psychiatry Genetics SNP Humans Genetic Predisposition to Disease Molecular Biology Aged Clinical Genetics Sickle Cell Disease business.industry Organic Chemistry Chemical Compounds Biology and Life Sciences Proteins medicine.disease Hormones Genotype frequency Health Care Hemoglobinopathies People and places business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 11, p e0224886 (2019) |
| ISSN: | 1932-6203 |
| Popis: | PurposeFrequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, rs10877969, has been associated with pain and disability in other pain populations. In patients with SCD, clinical factors such as pain and stress have been associated with increased health care utilization, but it is not known if the presence of the AVPR1A SNP plays a role in this observation. The study purpose was to explore the relationships between rs10877969 and self-reported pain, stress, and acute care utilization events among individuals with SCD.MethodsIn a cross-sectional investigation of outpatients with SCD, participants completed PAINReportIt®, a computerized pain measure, to describe their pain experience and contributed blood or saliva samples for genetic analysis. We extracted emergency department and acute care utilization from medical records.ResultsThe SNP genotype frequencies (%) for this sample were CC 30 (28%), CT 44 (41%), TT 33 (31%). Acute care utilization and stress as an aggravator of pain were significantly associated with the rs10877969 genotype (p = .02 and p = .002, respectively). The CT genotype had the highest mean utilization and CC genotype was associated with not citing stress as a pain aggravator. Chronic pain was not associated with rs10877969 (p = .41).ConclusionThis study shows that rs10877969 is related to indicators of stress and acute pain. Further research is recommended with other measures of stress and acute pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |