S -nitrosylation/activation of COX-2 mediates NMDA neurotoxicity
| Autor: | Lynda D. Hester, Sangwon F. Kim, Solomon H. Snyder, Jing Tian |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
N-Methylaspartate
PDZ domain Biotin Nitric Oxide Synthase Type II Receptors N-Methyl-D-Aspartate Nitric oxide Mice chemistry.chemical_compound Enzyme activator Cerebellum medicine Animals Humans Neurons Multidisciplinary Cell Death biology Neurotoxicity Glutamate receptor Brain Membrane Proteins S-Nitrosylation Biological Sciences medicine.disease Molecular biology Cell biology Enzyme Activation nervous system chemistry Cyclooxygenase 2 biology.protein NMDA receptor Cyclooxygenase Protein Binding |
| Zdroj: | Proceedings of the National Academy of Sciences. 105:10537-10540 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Glutamate/ N -methyl- d -aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S -nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX-2 with the generated NO S -nitrosylating and activating the enzyme. Selective disruption of nNOS—COX-2 binding prevents NMDA neurotoxicity. |
| Databáze: | OpenAIRE |
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