Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice
| Autor: | Ulla Vogel, Sandra Goericke-Pesch, Ismo K. Koponen, Karin Sørig Hougaard, Anna Jacobsen Lauvas, Francesco Marchetti, Astrid Skovmand, Keld Alstrup Jensen, Alexander C. Ø. Jensen, Clotilde Maurice |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Litter (animal) Reproductive toxicity Health Toxicology and Mutagenesis In utero 010501 environmental sciences Toxicology 01 natural sciences Mice Pregnancy Testis Testes reproductive and urinary physiology media_common Epididymis Inhalation exposure Inhalation Exposure 0303 health sciences Sperm Count Reproduction General Medicine Spermatozoa Daily sperm production Airway exposure Maternal Exposure Prenatal Exposure Delayed Effects Sperm Motility Female Sperm quality Offspring media_common.quotation_subject lcsh:Industrial hygiene. Industrial welfare Mice Inbred Strains Fertility Biology Andrology Computer assisted sperm analysis 03 medical and health sciences Soot lcsh:RA1190-1270 Animals 030304 developmental biology 0105 earth and related environmental sciences lcsh:Toxicology. Poisons Research Sperm Nanoparticles Spermatogenesis lcsh:HD7260-7780.8 |
| Zdroj: | Skovmand, A, Jensen, A C Ø, Maurice, C, Marchetti, F, Lauvås, A J, Koponen, I K, Jensen, K A, Goericke-Pesch, S, Vogel, U B & Hougaard, K S 2019, ' Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice ', Particle and Fibre Toxicology, vol. 16, no. 13 . https://doi.org/10.1186/s12989-019-0295-3 Particle and Fibre Toxicology, Vol 16, Iss 1, Pp 1-13 (2019) Skovmand, A, Jensen, A C Ø, Maurice, C, Marchetti, F, Lauvås, A J, Koponen, I K, Jensen, K A, Goericke-Pesch, S, Vogel, U & Hougaard, K S 2019, ' Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice ', Particle and Fibre Toxicology, vol. 16, 13 . https://doi.org/10.1186/s12989-019-0295-3 Particle and Fibre Toxicology |
| Popis: | BackgroundPrevious findings indicate that in utero exposure to nanoparticles may affect the reproductive system in male offspring. Effects such as decreased sperm counts and testicular structural changes in F1 males have been reported following maternal airway exposure to carbon black during gestation. In addition, a previous study in our laboratory suggested that the effects of in utero exposure of nanoparticles may span further than the first generation, as sperm content per gram of testis was significantly lowered in F2 males. In the present study we assessed male fertility parameters following in utero inhalation exposure to carbon black in four generations of mice.ResultsFilter measurements demonstrated that the time-mated females were exposed to a mean total suspended particle mass concentration of 4.79 ± 1.86 or 33.87 ± 14.77 mg/m3 for the low and high exposure, respectively. The control exposure was below the detection limit (LOD 0.08 mg/m3). Exposure did not affect gestation and litter parameters in any generation. No significant changes were observed in body and reproductive organ weights, epididymal sperm parameters, daily sperm production, plasma testosterone or fertility.ConclusionIn utero exposure to carbon black nanoparticles, at occupationally relevant exposure levels, via maternal whole body inhalation did not affect male-specific reproductive, fertility and litter parameters in four generations of mice. |
| Databáze: | OpenAIRE |
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