Derivatization of 11-alpha-hydroxyprogesterone using phosphoramidite chemistry
| Autor: | Jari Hovinen, Janne Ketola, Pertti Hurskainen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Phosphoramidite medicine.medical_treatment Organic Chemistry Biomedical Engineering Pharmaceutical Science Bioengineering Oligonucleotide synthesis Combinatorial chemistry Steroid chemistry.chemical_compound Organophosphorus Compounds chemistry Competitive binding medicine Hydroxyprogesterones Hydroxyprogesterone Organic chemistry Combinatorial Chemistry Techniques Derivatization Biotechnology Conjugate |
| Zdroj: | Bioconjugate chemistry. 20(3) |
| ISSN: | 1520-4812 |
| Popis: | The well-known phosphoramidite chemistry routinely used in solid-phase oligonucleotide synthesis is exploited here in the preparation of steroid conjugates in solution. The applicability of the method is tested by conjugating one nucleosidic and one non-nucleosidic phosphoramidite building block to 11-alpha-hydroxyprogesterone. The suitability of one of the conjugates synthesized (5) for a competitive binding assay is also demonstrated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|