The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): Study protocol for a randomised controlled trial

Autor: Devenney, K.E., Sanders, M.L., Lawlor, B., Olde Rikkert, M.G.M., Schneider, S., Aaronson, J.A., Abeln, V., Claassen, J.A.H.R., Coen, R.F., Guinan, E.M., Ferguson, D., Kessels, R.P.C., Meeusen, R., Montag, C., Murphy, R.T., Polidori, M.C., Reuter, M, Strüder, H.K., Thijssen, D.H.J., Vogt, T., Walsh, C., Weber, B., Hoblyn, J., Eustace, A., McGreevy, C., Denihan, A., Kinsella, J., Lyons, D., Kennelly, S.
Přispěvatelé: Spine Research Group, Advanced Rehabilitation Technology & Science, Human Physiology and Sports Physiotherapy Research Group, Physiotherapy, Human Physiology and Anatomy
Rok vydání: 2017
Předmět:
Male
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1]
Trail Making Test
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Neuropsychological Tests
law.invention
RC1200
0302 clinical medicine
Randomized controlled trial
law
Medicine
Exercise intervention
030212 general & internal medicine
Cognitive decline
Mild cognitive impairment (MCI)
Quality Of Life
Cognitive reserve
exercise therapy
medicine.diagnostic_test
exercise
Frailty
Montreal Cognitive Assessment
Neuropsychological test
Middle Aged
Multicenter Study
Treatment Outcome
Randomized Controlled Trial
Disease Progression
Female
medicine.medical_specialty
BF
Health Promotion
03 medical and health sciences
mild cognitive impairment
cognitive dysfunction
Journal Article
Aerobic exercise
Humans
cognitive function
Aged
Neuro- en revalidatiepsychologie
epigenetics
business.industry
brain structure
Neuropsychology and rehabilitation psychology
Physical Activity
Plasticity and Memory [DI-BCB_DCC_Theme 3]
medicine.disease
Physical therapy
Geriatrics and Gerontology
business
aged
80 and over
030217 neurology & neurosurgery
Zdroj: BMC Geriatrics, 17, 1, pp. 75-75
BMC Geriatrics, 17, 75-75
ISSN: 1471-2318
Popis: Contains fulltext : 174222.pdf (Publisher’s version ) (Open Access) BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI. This study aims to determine the effects of an extensive exercise programme on the progression of MCI. METHODS/DESIGN: This randomised controlled clinical intervention study will take place across three European sites. Seventy-five previously sedentary patients with a clinical diagnosis of MCI will be recruited at each site. Participants will be randomised to one of three groups. One group will receive a standardised 1-year extensive aerobic exercise intervention (3 units of 45 min/week). The second group will complete stretching and toning (non-aerobic) exercise (3 units of 45 min/week) and the third group will act as the control group. Change in all outcomes will be measured at baseline (T0), after six months (T1) and after 12 months (T2). The primary outcome, cognitive performance, will be determined by a neuropsychological test battery (CogState battery, Trail Making Test and Verbal fluency). Secondary outcomes include Montreal Cognitive Assessment (MoCA), cardiovascular fitness, physical activity, structural changes of the brain, quality of life measures and measures of frailty. Furthermore, outcome variables will be related to genetic variations on genes related to neurogenesis and epigenetic changes in these genes caused by the exercise intervention programme. DISCUSSION: The results will add new insights into the prevailing notion that exercise may slow the rate of cognitive decline in MCI. TRIAL REGISTRATION: ClinicalTrials.gov NCT02913053. 10 p.
Databáze: OpenAIRE
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