A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs
| Autor: | Vladimir Palicka, Tomáš Zima, Svetlana Morosyuk, Ana K. Stankovic, Richard Prusa, Robert H. Christenson, Elizabeth Plokhoy, Julie Berube, Denise Uettwiller-Geiger, Kristin Shaw, Alan H.B. Wu, Aparna Jha Ahuja |
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| Rok vydání: | 2020 |
| Předmět: |
Phenytoin
Blood Specimen Collection 030213 general clinical medicine medicine.medical_specialty medicine.diagnostic_test Digoxin business.industry General Medicine Carbamazepine Gastroenterology Acetaminophen 03 medical and health sciences 0302 clinical medicine Therapeutic drug monitoring 030220 oncology & carcinogenesis Internal medicine medicine Humans Vancomycin Drug Monitoring Blood Collection Tube business Vacutainer medicine.drug |
| Zdroj: | The Journal of Applied Laboratory Medicine. 5:671-685 |
| ISSN: | 2475-7241 2576-9456 |
| DOI: | 10.1093/jalm/jfaa033 |
| Popis: | Background Some therapeutic drugs are unstable during sample storage in gel tubes. BD Vacutainer® Barricor™ Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PST™, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7 days. Methods Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0 h), after 48 h of storage at room temperature and on day 7 (after additional 5 days of refrigerated storage). The performance of BD Barricor tube was evaluated for each drug by comparing BD Barricor samples with samples from the other tubes at 0 h from the same participant; stability was evaluated by comparing test results from the same tube at 0 h, 48 h, and 7 days. Results At 0 h, BD Barricor showed clinically equivalent results for selected therapeutic drugs compared with the other tubes, except phenytoin in BD PST. Phenytoin samples ≥20 µg/mL in BD PST had 10–12% lower values than samples in BD Barricor. During sample storage, all selected drugs remained stable for 7 days in BD Barricor and in serum aliquots. In BD PST, all drugs remained stable except phenytoin and carbamazepine and in BD PST II except for phenytoin. Conclusion The BD Barricor Tube is effective for the collection and storage of plasma blood samples for therapeutic drug monitoring without sample aliquoting. |
| Databáze: | OpenAIRE |
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