Severe gastrointestinal disease due to HIV-1-seronegative AIDS
| Autor: | Phillip D. Smith, Klaus Mönkemüller, Lucia C. Fry, Steffen Rickes, Decker Jm |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Gastrointestinal Diseases Rectum Gastroenterology Asymptomatic Diagnosis Differential Acquired immunodeficiency syndrome (AIDS) Internal medicine HIV Seronegativity medicine Humans Esophagus Acquired Immunodeficiency Syndrome business.industry Wasting Syndrome virus diseases Middle Aged medicine.disease Esophageal Ulcer Diarrhea medicine.anatomical_structure Gastrointestinal disease HIV-1 medicine.symptom business Odynophagia |
| Zdroj: | Zeitschrift fur Gastroenterologie. 45(8) |
| ISSN: | 0044-2771 |
| Popis: | An HIV-1 seronegative man presented with odynophagia, dysphagia, diarrhea, tenesmus and a 50-lb weight loss. A large esophageal ulcer and a rectal fissure were identified endoscopically. Stool samples and biopsy specimens from the esophageal ulcer, duodenum, colon and rectum were negative for pathogens. Seronegative AIDS was suspected, and high levels of HIV-1 mRNA (> 242,000 copies/mL) were detected. The esophageal ulcer responded to oral steroids and the HIV-1 infection to highly active anti-retroviral therapy (HAART). The virus isolated from the patient and an HIV-1 seropositive, asymptomatic, female sex worker with whom he had recently terminated a one-year heterosexual relationship showed sequence homology, indicating her as the source of his virus. The unusual presentation of severe gastrointestinal disease in an HIV-1 seronegative man with HIV-1 viremia underscores the importance of including AIDS in the differential diagnosis of wasting syndrome (i. e., B-type symptoms such as fever, night sweats, weight loss) in patients who are HIV-1 seronegative but at risk for AIDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|