Triterpenoid saponins, new metalloprotease snake venom inhibitors isolated from Pentaclethra macroloba
| Autor: | Fábio Kiss Ticli, João José Franco, Andreimar M. Soares, Renata S. Fernandes, Silvana Giuliatti, Suely Vilela Sampaio, Jocivânia O. da Silva, Maurício V. Mazzi, Paulo Pereira, Clayton Z. Oliveira |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Serine Proteinase Inhibitors food.ingredient Molecular Sequence Data Antivenom Antihemorrhagic Hemorrhage Venom Pharmacology Toxicology complex mixtures Phospholipases A Mice food Crotalid Venoms Animals Pentaclethra macroloba Envenomation Blood Coagulation Triterpenoid saponin chemistry.chemical_classification Fibrin biology Plant Extracts Circular Dichroism Fibrinogen Plants Saponins biology.organism_classification Triterpenes Baccharis Carbohydrate Sequence chemistry Biochemistry Snake venom Bothrops Spectrophotometry Ultraviolet Snake Venoms |
| Zdroj: | Toxicon. 50:283-291 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2007.03.024 |
| Popis: | We report here the antiproteolytic and antihemorrhagic properties of triterpenoid saponin inhibitors, named macrolobin-A and B, from Pentaclethra macroloba, against Bothrops snake venoms. The inhibitors were able to neutralize the hemorrhagic, fibrin(ogen)olytic, and proteolytic activities of class P-I and P-III metalloproteases isolated from B. neuwiedi and B. jararacussu venoms. Clotting and fibrinogenolytic activities induced by snake venoms and isolated thrombin-like enzymes were partially inhibited. Furthermore, the potential use of these inhibitors to complement antivenom therapy as an alternative treatment and/or used as molecular models for development of new therapeutical agents in the treatment of snake bite envenomations needs to be evaluated in future studies. |
| Databáze: | OpenAIRE |
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