Urinary d-glucaric acid and serum hepatic enzyme levels in chronic alcoholics
| Autor: | Victoria Lareu, M. Carmen Pardiñas, Francisco Bernabeu, J. Manuel Paz, J. Carlos Tutor, Angel Alvarez-Prechous |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system media_common.quotation_subject Clinical Biochemistry Alcohol Excretion Glucaric Acid chemistry.chemical_compound Internal medicine medicine Humans Enzyme inducer Aged media_common chemistry.chemical_classification biology D-Glucaric Acid Sugar Acids Chronic alcoholic gamma-Glutamyltransferase General Medicine Middle Aged Abstinence Alcoholism Enzyme Endocrinology Liver chemistry Chronic Disease biology.protein |
| Zdroj: | Clinical Biochemistry. 21:193-198 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/0009-9120(88)90010-0 |
| Popis: | Urinary D-glucaric acid (DGA) and the activities of gamma-glutamyl transferase (GGT) and other hepatic enzymes in serum were determined in 33 noncirrhotic male alcoholics who had continued to consume alcohol until at least 24 h prior to the taking of samples. DGA excretion was significantly greater in them than in a group of 30 healthy controls (p less than 0.001), exceeding the upper reference level in 38% of the alcoholic cases (as compared with 88% for GGT). In the alcoholic patients, there was highly significant correlation between urinary DGA and serum GGT (r = 0.613, p less than 0.001), suggesting that in both cases the increased levels are due to enzyme induction. None of the biochemical variables studied were significantly correlated with estimated daily alcohol consumption. Urinary DGA levels fell off rapidly with abstinence, and in 31 alcoholic patients who had consumed no alcohol for 5 days, there was no statistically significant correlation between DGA excretion and serum GGT (r = 0.158, p congruent to 0.4). |
| Databáze: | OpenAIRE |
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