Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder
| Autor: | Aline Vidal, Maria Lucia Vellutini Pimentel, Carlos Otávio Brandão, Leonilda M. B. Santos, Letícia Fezer Mansur, Raphael P. S. Quintiliano, Alessandro S. Farias, Vinícius O. Boldrini |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cytotoxicity Immunologic T-Lymphocytes Immunology Pathogenesis 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine Immunology and Allergy Cytotoxic T cell Humans Neuroinflammation B-Lymphocytes Neuromyelitis optica Effector business.industry Neuromyelitis Optica Middle Aged medicine.disease Granzyme B 030104 developmental biology Neurology Methylprednisolone Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of neuroimmunology. 340 |
| ISSN: | 1872-8421 |
| Popis: | Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds. |
| Databáze: | OpenAIRE |
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