The Contribution of Excision Repair Cross-complementing Group 1 Genotypes to Colorectal Cancer Susceptibility in Taiwan
| Autor: | Chi Li Gong, Te Cheng Yueh, Chia-Wen Tsai, Chun Kai Fu, Shiou Ting Yen, Hsin Ting Li, Da Tian Bau, Wen Shin Chang, Jen Sheng Pei, Chieh Lun Hsiao, Ming Hsien Wu, An-Kuo Chou |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Alcohol Drinking Genotype Colorectal cancer Taiwan 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Genetic Predisposition to Disease Allele Allele frequency Predictive marker business.industry Smoking General Medicine Odds ratio Middle Aged Endonucleases medicine.disease Confidence interval DNA-Binding Proteins 030104 developmental biology Case-Control Studies Lymphatic Metastasis 030220 oncology & carcinogenesis Female ERCC1 Colorectal Neoplasms business |
| Zdroj: | Anticancer Research. 37:2307-2313 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11568 |
| Popis: | AIM To evaluate the contribution of ERCC1 rs11615 and rs3212986 genotypes regarding the risk of colorectal cancer (CRC) in Taiwan. MATERIALS AND METHODS In this case-control study, ERCC1 rs11615 and rs3212986 genotypes and their interaction with consumption of cigarettes and alcohol in determining CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. RESULTS The percentages of CC, CT and TT for ERCC1 rs11615 genotype were 44.2%, 36.2% and 19.6% in the CRC group and 49.7%, 38.4% and 11.9% in the control group, respectively (p for trend=0.0158). The allelic frequency distribution analysis showed that the variant T allele of ERCC1 rs11615 conferred increased CRC susceptibility to the wild-type C allele (odds ratio (OR)=1.34, 95% confidence interval (CI)=1.08-1.67, p=0.0079). As for the gene-lifestyle interaction, there were obvious joint effects of ERCC1 rs11615 genotype on the risk of CRC among ever smokers and alcohol drinkers, but not non-smokers or non-drinkers. There is a positive correlation of ERCC1 rs11615 genotype with lymph node metastasis, but not other CRC prognosis, including tumor size and location. CONCLUSION ERCC1 rs11615 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate these findings. |
| Databáze: | OpenAIRE |
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