Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans
| Autor: | Justin D. Tubbs, Laura K. Case, Eleni Frangos, Diana Bharucha-Goebel, Nima Ghitani, Håkan Olausson, Dimah Saade, Mark H. Pitcher, Jonathan Cole, Nicholas Madian, Aaron Necaise, Micaela V. McCall, Jaquette Liljencrantz, Marcin Szczot, Alexander T. Chesler, Sandra Donkervoort, A. Reghan Foley, Megan Bradson, Tracy Ogata, Carsten G. Bönnemann, M. Catherine Bushnell |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Myelinated fiber Adult Male Science Sensation General Physics and Astronomy Sensory system General Biochemistry Genetics and Molecular Biology Ion Channels Article 03 medical and health sciences Young Adult 0302 clinical medicine Deep tissue Pressure Medicine Humans Aged Skin Multidisciplinary Proprioception business.industry Nerve Block General Chemistry Middle Aged Mechanoreceptor Pressure sensation 030104 developmental biology medicine.anatomical_structure Touch PIEZO2 Gene Mutation Sensation Disorders Somatosensory system Female Peripheral nervous system business Neuroscience Mechanoreceptors 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2041-1723 |
| Popis: | The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations of patients with rare sensory disorders, as well as nerve blocks in typical individuals, to probe the neural and genetic mechanisms for detecting non-painful pressure. We show that the ability to perceive innocuous pressures is lost when myelinated fiber function is experimentally blocked in healthy volunteers and that two patients lacking Aβ fibers are strikingly unable to feel innocuous pressures at all. We find that seven individuals with inherited mutations in the mechanoreceptor PIEZO2 gene, who have major deficits in touch and proprioception, are nearly as good at sensing pressure as healthy control subjects. Together, these data support a role for Aβ afferents in pressure sensation and suggest the existence of an unknown molecular pathway for its detection. The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses. |
| Databáze: | OpenAIRE |
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