Merkel Cell Carcinoma of the Lower Extremity
| Autor: | Giovanni Fanelli, Davide Lazzeri, Benedetta Barbieri, Giordano Giannotti, Alessandro Massei, Livio Colizzi, Paolo Viacava, Daniele Pagnini |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Carcinoma medicine Humans Aged Aged 80 and over Leg Chemotherapy business.industry Merkel cell carcinoma Cancer Fascia Guideline Middle Aged medicine.disease Surgery Carcinoma Merkel Cell Radiation therapy medicine.anatomical_structure Female Lymphadenectomy business |
| Zdroj: | Annals of Plastic Surgery. 62:83-86 |
| ISSN: | 0148-7043 |
| Popis: | Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous malignancy that predominantly arises in the head and neck region. We describe clinical features, diagnosis, and treatment in 4 cases of MCC, presenting an uncommon female predominant occurrence and an unusual primary site: the lower limb. In all cases diagnosis was established by histopathologic examination. Primary MCC and locally recurrence disease were treated in all patients with a wide surgical excision (3-cm margin) including fascia. Lymphadenectomy was reserved for a patient with clinical evidence of nodal involvement. Both chemotherapy administered in 2 cases and radiotherapy in 1 case produced limited responses. Early diagnosis is critical because this tumor is aggressive and has a high rate of local recurrence and metastatic spread. However, its nondistinctive appearance frequently delays diagnosis and its rarity avoids an optimal treatment guideline setting. |
| Databáze: | OpenAIRE |
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