COVID-19-related vasculopathy of the brain
| Autor: | Edward B Jude, Hui Wen Liang, Chris Douglass, Sai Man Mung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Case Report Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system Pandemic medicine Humans Cognitive decline Stroke Pandemics Aged Cerebral Hemorrhage business.industry SARS-CoV-2 COVID-19 Brain General Medicine medicine.disease stroke Cerebral amyloid angiopathy Presentation (obstetrics) Cytokine storm business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| Popis: | The COVID-19 pandemic is revealing growing reports of atypical presentation of the disease beyond the respiratory system. SARS-CoV-2 infection has been linked to multisystem vasculopathy including cardiopulmonary, cerebral and renal vasculature, potentially brought on by a dysregulated host immune response in a probable setting of a cytokine storm. Here, we describe a case of a previously healthy and active 74-year-old man presenting with acute cognitive decline with preceding non-specific influenza-like symptoms. He was then diagnosed with cerebral amyloid angiopathy (CAA)-associated intracerebral haemorrhage and was found to be COVID-19 positive. COVID-19-induced immune response may have further compromised the cerebral vessels already weakened by CAA, triggering multiple microhaemorrhages leading to clinical presentation. The limited evidence about the heterogeneity of COVID-19 manifestations suggests that clinicians should be aware and screen for concurrent COVID-19 in patients presenting with neurological features during the peak of this pandemic, as this offers the best chance for better clinical outcome. |
| Databáze: | OpenAIRE |
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