Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin
| Autor: | Daniel Schnepf, Nils Lycke, Valentina Bernasconi, Hans Henrik Gad, Jan Becker, Yakup Tanriver, Karolina Ebert, Rune Hartmann, Liang Ye, Peter Staeheli |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Thymic stromal lymphopoietin medicine.medical_treatment T cell Immunity Mucosal/drug effects Immunology Biology Adaptive Immunity Virus Dendritic Cells/drug effects 03 medical and health sciences 0302 clinical medicine Immune system Orthomyxoviridae Infections Thymic Stromal Lymphopoietin medicine Immunology and Allergy Animals Influenza Vaccines/administration & dosage Interleukins/administration & dosage Immunity Mucosal Cells Cultured Microfold cell Receptors Interferon Mice Knockout Mice Inbred BALB C Cytokines/genetics Orthomyxoviridae Infections/immunology Interleukins Immunization/methods Receptors Interferon/genetics Germinal center Dendritic Cells Adaptive Immunity/drug effects Acquired immune system Influenza A virus/drug effects Antibody Formation/drug effects Mice Inbred C57BL 030104 developmental biology Cytokine medicine.anatomical_structure Influenza A virus Influenza Vaccines Mice Inbred DBA Antibody Formation Cytokines Immunization 030215 immunology |
| Zdroj: | Ye, L, Schnepf, D, Becker, J, Ebert, K, Tanriver, Y, Bernasconi, V, Gad, H H, Hartmann, R, Lycke, N & Staeheli, P 2019, ' Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin ', Nature Immunology, vol. 20, no. 5, pp. 593-601 . https://doi.org/10.1038/s41590-019-0345-x |
| Popis: | Interferon-λ (IFN-λ) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-λ in adaptive immunity is far less clear. Here, we report that mice deficient in IFN-λ signaling exhibited impaired CD8+ T cell and antibody responses after infection with a live-attenuated influenza virus. Virus-induced release of IFN-λ triggered the synthesis of thymic stromal lymphopoietin (TSLP) by M cells in the upper airways that, in turn, stimulated migratory dendritic cells and boosted antigen-dependent germinal center reactions in draining lymph nodes. The IFN-λ–TSLP axis also boosted production of the immunoglobulins IgG1 and IgA after intranasal immunization with influenza virus subunit vaccines and improved survival of mice after challenge with virulent influenza viruses. IFN-λ did not influence the efficacy of vaccines applied by subcutaneous or intraperitoneal routes, indicating that IFN-λ plays a vital role in potentiating adaptive immune responses that initiate at mucosal surfaces. The role of IFN-λ in adaptive immunity is not well characterized. Staeheli and colleagues show that in the lungs, IFN-λ elicits production of the cytokine TSLP from M cells and that this in turn is essential for effective adaptive immunity and control of infection with influenza virus. |
| Databáze: | OpenAIRE |
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