East-West gradient in the incidence of inflammatory bowel disease in Europe:The ECCO-EpiCom inception cohort
| Autor: | I Mihu, Konstantinos Katsanos, K. Ladefoged, I. Kaimakliotis, J. Olsen, Vibeke Andersen, D. Martinez-Ares, Naila Arebi, Ebbe Langholz, Johan Burisch, A. De Padova, L. Barros, Svetlana Turcan, Daniela Lazăr, E.V. Tsianos, Yaroslava Zhulina, Jonas Halfvarson, Veronica Moset Hernandez, O Tighineanu, Shaji Sebastian, Niels Thorsgaard, Ida Vind, Y. Bailey, Silvija Čuković-Čavka, Jens Frederik Dahlerup, Peter L. Lakatos, Adrian Goldis, Olga Shonová, Gediminas Kiudelis, K R Nielsen, Dana Duricova, Niels C Pedersen, Riina Salupere, Matteo Martinato, Pekka Collin, Pia Munkholm, Pekka Manninen, Søren Avnstrøm, Monica Milla, Shmuel Odes, Fernando Magro, Guido Lupinacci, Einar Björnsson, Inna Nikulina, M Beltrami, G. Ragnarsson, Marko Brinar, Laszlo Lakatos, Sven Almer, Doron Schwartz, Simon Laiggard Krabbe, Limas Kupčinskas, Elena Belousova, Renata D'Incà |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Colorectal cancer Inflammatory bowel disease Young Adult Crohn Disease Internal medicine Epidemiology Inflammatory bowel disease (IBD) inception cohort East-West gradient medicine Humans Europe Eastern Prospective Studies skin and connective tissue diseases Aged Aged 80 and over Crohn's disease medicine.diagnostic_test business.industry Incidence Incidence (epidemiology) Gastroenterology Colonoscopy Middle Aged Inflammatory Bowel Diseases medicine.disease INCEPTION COHORT Ulcerative colitis digestive system diseases Surgery Endoscopy Europe Colitis Ulcerative Female sense organs business |
| Zdroj: | Burisch, J, Pedersen, N, Čuković-Čavka, S, Brinar, M, Kaimakliotis, I, Duricova, D, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Andersen, V, Krabbe, S, Dahlerup, J F, Salupere, R, Nielsen, K R, Olsen, J, Manninen, P, Collin, P, Tsianos, E V, Katsanos, K H, Ladefoged, K, Lakatos, L, Björnsson, E, Ragnarsson, G, Bailey, Y, Odes, S, Schwartz, D, Martinato, M, Lupinacci, G, Milla, M, De Padova, A, D'inca, R, Beltrami, M, Kupcinskas, L, Kiudelis, G, Turcan, S, Tighineanu, O, Mihu, I, Magro, F, Barros, L F, Goldis, A, Lazar, D, Belousova, E, Nikulina, I, Hernandez, V, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J & Arebi, N 2014, ' East-West gradient in the incidence of inflammatory bowel disease in Europe : The ECCO-EpiCom inception cohort ', Gut, vol. 63, no. 4, pp. 588-597 . https://doi.org/10.1136/gutjnl-2013-304636 ResearcherID Burisch, J, Pedersen, N, Cukovic-Cavka, S, Brinar, M, Kaimakliotis, I, Duricova, D, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Andersen, V, Krabbe, S L, Dahlerup, J F, Salupere, R, Nielsen, K R, Olsen, J, Manninen, P, Collin, P, Tsianos, E V, Katsanos, K H, Ladefoged, K, Lakatos, L, Björnsson, E, Ragnarsson, G, Bailey, Y, Odes, S, Schwartz, D, Martinato, M, Lupinacci, G, Milla, M, De Padova, A, D'Incà, R, Beltrami, M, Kupcinskas, L, Kiudelis, G, Turcan, S, Tighineanu, O, Mihu, I, Magro, F, Barros, L F, Goldis, A, Lazar, D, Belousova, E, Nikulina, I, Hernandez, V M, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N & EpiCom Group 2014, ' East-West gradient in the incidence of inflammatory bowel disease in Europe : The ECCO-EpiCom inception cohort ', Gut, vol. 63, no. 4, pp. 588-597 . https://doi.org/10.1136/gutjnl-2013-304636 |
| Popis: | Objective: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East-West gradient in the incidence of IBD in Europe exists. Design: A prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience. Results: 1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn's disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100 000 in 2010 for CD were 6.5 (range 0-10.7) in Western European centres and 3.1 (range 0.4-11.5) in Eastern European centres, for UC 10.8 (range 2.9-31.5) and 4.1 (range 2.4-10.3), respectively, and for IBDU 1.9 (range 0-39.4) and 0 (range 0-1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy. Conclusions: An East-West gradient in IBD incidence exists in Europe. Among this inception cohort-including indolent and aggressive cases-international guidelines for diagnosis and initial treatment are not being followed uniformly by physicians. |
| Databáze: | OpenAIRE |
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