Venous Access Port–Related Bacteremia in Patients with Acquired Immunodeficiency Syndrome or Cancer: The Reservoir as a Diagnostic and Therapeutic Tool
| Autor: | Marie Cécile Douard, Catherine Benoit, Guillaume Arlet, Pascale Longuet, Catherine Leport, Jean-Michel Molina |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Microbiology (medical) Catheterization Central Venous Staphylococcus aureus medicine.medical_specialty Lung Neoplasms Lymphoma medicine.drug_class Antibiotics Bacteremia Breast Neoplasms Pilot Projects Gastroenterology Catheters Indwelling Port (medical) Neoplasms Internal medicine Staphylococcus epidermidis medicine Humans Blood culture Antibacterial agent AIDS-Related Opportunistic Infections medicine.diagnostic_test business.industry Staphylococcal Infections medicine.disease Anti-Bacterial Agents Surgery Catheter Infectious Diseases Female Viral disease Complication business |
| Zdroj: | Clinical Infectious Diseases. 32:1776-1783 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/320746 |
| Popis: | To describe the rate of response to an antibiotic-lock technique (ALT) in the treatment of venous access port (VAP)--related bacteremia and to analyze the role of the reservoir in the persistence of infection, we reported the data from 12 human immunodeficiency virus--infected and 8 oncologic patients with VAP-related bacteremia. The ALT consisted of intracatheter delivery of antibiotics and was associated with a systemic antibiotic infusion. We monitored clinical manifestations and performed qualitative and quantitative blood cultures during and at the end of the treatment. Four patients had catheters removed before antibiotic treatment. Of the 16 patients who were treated with the ALT, 5 (31%) were cured, as determined by negative cultures of blood and of samples from the catheter; 2 (12.5%) were cured but had recurrent infection with another microorganism; and 9 (56%) had persistent positive cultures of blood and of samples from the tip, reservoir, or both of the VAP. Limited efficacy of the ALT might be explained by the presence of deposits of fibrin that include clusters of bacteria inside the reservoir of the port. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|