Delayed injection of polypyrrole doped with iodine particle suspension after spinal cord injury in rats improves functional recovery and decreased tissue damage evaluated by 3.0 Tesla in vivo magnetic resonance imaging
| Autor: | Laura Alvarez-Mejia, Axayacatl Morales-Guadarrama, Guillermo J. Cruz, Camilo Ríos, Rodrigo Mondragón-Lozano, Roberto Olayo, Juan Morales, Stephanie Sánchez-Torres, Maria Guadalupe Olayo, Marisela Méndez-Armenta, Araceli Diaz-Ruiz, Omar Fabela, Hermelinda Salgado-Ceballos, Ernesto Roldan-Valadez |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Polymers Context (language use) 02 engineering and technology Rats Sprague-Dawley Lesion 03 medical and health sciences 0302 clinical medicine In vivo Fractional anisotropy medicine Animals Effective diffusion coefficient Pyrroles Orthopedics and Sports Medicine Spinal cord injury Spinal Cord Injuries medicine.diagnostic_test business.industry Nervous tissue Magnetic resonance imaging 021001 nanoscience & nanotechnology medicine.disease Rats Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Female Surgery Neurology (clinical) medicine.symptom 0210 nano-technology Nuclear medicine business 030217 neurology & neurosurgery Iodine |
| Zdroj: | The Spine Journal. 17:562-573 |
| ISSN: | 1529-9430 |
| DOI: | 10.1016/j.spinee.2016.02.012 |
| Popis: | Background Context Traumatic spinal cord injury (SCI) causes irreversible damage with loss of motor, sensory, and autonomic functions. Currently, there is not an effective treatment to restore the lost neurologic functions. Purpose Injection of polypyrrole-iodine(PPy-I) particle suspension is proposed as a therapeutic strategy. Study Design This is an in vivo animal study. Methods This study evaluates the use of such particles in rats after SCI by examining spared nervous tissue and the Basso, Beattie, and Bresnahan (BBB) scale to evaluate the functional outcome. Diffusive magnetic resonance imaging (MRI) was employed to measure the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) as non-invasive biomarkers of damage after SCI. Results Fractional anisotropy decreased, whereas ADC increased in all groups after the lesion. There were significant differences in FA when compared with the SCI-PPy-I group versus the SCI group (p 2 =0.449, p 2 =0.395, p 2 =0.367, p 2 =0.421, p Conclusions The results suggested that PPy-I is neuroprotective as it decreased the amount of damaged tissue while improving the motor function. Non-invasive MRI proved to be useful in the characterization of SCI and recovery. |
| Databáze: | OpenAIRE |
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