Effects of corticosteroids vs halofuginone on vocal fold wound healing in an ovine model

Autor: Jacqueline Allen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Laryngoscope Investigative Otolaryngology, Vol 6, Iss 4, Pp 786-793 (2021)
Laryngoscope Investigative Otolaryngology
ISSN: 2378-8038
Popis: Objectives To evaluate antifibrotic effects of corticosteroids and halofuginone, a small molecule inhibitor of Smad3, in an ovine model of vocal fold (VF) injury. Methods Thirty sheep, using a paired study design, underwent controlled right VF injury by biopsy and then were treated with either no treatment, oral dexamethasone, intralesional triamcinolone, or oral halofuginone. Larynges were evaluated for histological evidence of fibrosis, immunohistochemical presence of Smad3, and vibratory parameters. Outcomes were compared across treatment groups. Results Following injury, VF collagen density decreased in both halofuginone‐treated and dexamethasone‐treated sheep but not in triamcinolone treated sheep. A significant difference was noted between halofuginone and triamcinolone treated sheep (27.8% vs 37%, P = .017). Elastin was preserved postinjury by halofuginone treatment in contrast with all steroid treated animals where significant loss of elastin was noted (P
Modulation of vocal fold healing and scar formation was examined in an ovine model testing a novel collagen type 1A inhibitor, halofuginone, against commonly used steroid medications, dexamethasone and triamcinolone. Halofuginone inhibited collagen to the same extent and protected elastin to a greater extent than steroid medications during VF healing. Further investigation of this compound and its molecular pathway is warranted.
Databáze: OpenAIRE
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