Polymeric biomaterials for the delivery of platinum-based anticancer drugs
| Autor: | Hansoo Park, Swapan Pramanick, Jihoon Kim, Duhwan Lee, Won Jong Kim |
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| Rok vydání: | 2015 |
| Předmět: |
Antitumor activity
Polymers business.industry Fda approval Biomedical Engineering chemistry.chemical_element Antineoplastic Agents Biocompatible Materials Nanotechnology Polymeric nanoparticles Cancer treatment Drug Delivery Systems chemistry Neoplasms Drug delivery Humans Nanoparticles Medicine General Materials Science Inorganic materials Cisplatin Head and neck Platinum business |
| Zdroj: | Biomaterials Science. 3:1002-1017 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/c5bm00039d |
| Popis: | Since cisplatin, cis-diamminedichloroplatinum(ii), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems. |
| Databáze: | OpenAIRE |
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