Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases

Autor:	Cigdem Sahin, Lilia Magomedova, Thais A. M. Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S. Alves, Fellipe J. G. Queiroz, Andressa S. de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patrícia C. N. Nogueira, Edilberto R. Silveira, Daniel C. Moreira, José Roberto Souza de Almeida Leite, Guilherme D. Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L. Cummins, Luiz A. S. Romeiro
Rok vydání:	2022
Předmět:	Male Gene Expression Lipid Metabolism Anacardic Acids Mice Inbred C57BL Molecular Docking Simulation PPAR gamma Mice HEK293 Cells Protein Domains 3T3-L1 Cells Drug Design Drug Discovery Animals Humans Nuts Molecular Medicine Anacardium PPAR alpha PPAR delta Zebrafish
Zdroj:	Journal of Medicinal Chemistry. 65:1961-1978
ISSN:	1520-4804 0022-2623
Popis:	Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds derived from phenolic lipids present in cashew nut shell liquid (CNSL), an abundant waste byproduct, in an effort to create effective, accessible, and sustainable drugs. Derivatives of anacardic acid and cardanol were tested for PPAR activity in HEK293 cell co-transfection assays, primary hepatocytes, and 3T3-L1 adipocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f8986169723c27031b9ffdf2af6b39 https://doi.org/10.1021/acs.jmedchem.1c01542 Zobrazit plný text záznamu