Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro

Autor:	Abhishek Gupta, Shalini Gupta, Ujjal Das, Surajit Sinha
Rok vydání:	2022
Předmět:	Pharmacology Carcinoma Organic Chemistry Biomedical Engineering Pharmaceutical Science Bioengineering Cell-Penetrating Peptides B7-H1 Antigen Morpholinos Cricetulus Cricetinae Animals Humans Guanidine Biotechnology
Zdroj:	Bioconjugate Chemistry. 33:907-917
ISSN:	1520-4812 1043-1802
Popis:	Cell-penetrating peptides (CPPs) are structurally diverse sophisticated tools endowed with high arginine content, amphipathicity, and well-adopted suitable secondary structures. Despite its capability of breaching the lipid barriers, CPP has major limitations such as
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7b1afd8abb1ba01c2583ed51550aa https://doi.org/10.1021/acs.bioconjchem.2c00129 Zobrazit plný text záznamu