A Look at the Safety Profile of Over-the-Counter Naproxen Sodium: A Meta-analysis
| Autor: | Vidhu Bansal, Howard Proskin, Terry Dex, Stephen Garreffa |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Naproxen business.industry Anti-Inflammatory Agents Non-Steroidal Analgesic Headache Nausea Nonprescription Drugs Naproxen Sodium Placebo Dizziness Anesthesia Toxicity medicine Adverse Drug Reaction Reporting Systems Humans Pharmacology (medical) Over-the-counter Self-administration Adverse effect business Randomized Controlled Trials as Topic medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 41:127-138 |
| ISSN: | 0091-2700 |
| DOI: | 10.1177/00912700122009935 |
| Popis: | As the trend for Americans to self-medicate continues to increase, it becomes important to review the safety of over-the-counter (OTC) medications. This article will review the safety of an OTC analgesic, Aleve® (naproxen sodium). The objective of this meta-analysis is to evaluate the frequency of occurrence of all adverse events in subjects taking various doses of OTC naproxen sodium as compared to placebo. These varying doses and dosage regimens were studied individually and consisted of 220 to 880 mg administered in single, multiple, and PRN (as needed) doses of naproxen sodium. This meta-analysis confirmed the favorable safety profile of naproxen sodium at OTC doses and established that the overall occurrence of adverse events with naproxen sodium was comparable and in some cases significantly lower than placebo. These results indicate that treatment with naproxen sodium may be highly beneficial from a clinical and economical perspective and safe when adhering to labeled directions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text