The time of maximum post-ischemic hyperperfusion indicates infarct growth following transient experimental ischemia
| Autor: | Richard B. Buxton, Michael Weller, Judith Artmann, Susanne Wegener, Andreas R. Luft, Eric C. Wong |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Central Nervous System Time Factors Anatomy and Physiology lcsh:Medicine Infarction Cardiovascular 030218 nuclear medicine & medical imaging Brain Ischemia Brain ischemia 0302 clinical medicine lcsh:Science Stroke Multidisciplinary Cerebral infarction Brain Cerebral Infarction Animal Models Magnetic Resonance Imaging Cerebral blood flow Neurology Anesthesia Cerebrovascular Circulation Reperfusion Injury Medicine Research Article Nervous System Physiology Cerebrovascular Diseases Ischemia Neuroimaging Neurological System 03 medical and health sciences Model Organisms medicine Animals Biology Ischemic Stroke business.industry lcsh:R Hemodynamics Blood flow medicine.disease Rats Disease Models Animal Rat lcsh:Q business Reperfusion injury 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 5, p e65322 (2013) |
| ISSN: | 1932-6203 |
| Popis: | After recanalization, cerebral blood flow (CBF) can increase above baseline in cerebral ischemia. However, the significance of post-ischemic hyperperfusion for tissue recovery remains unclear. To analyze the course of post-ischemic hyperperfusion and its impact on vascular function, we used magnetic resonance imaging (MRI) with pulsed arterial spin labeling (pASL) and measured CBF quantitatively during and after a 60 minute transient middle cerebral artery occlusion (MCAO) in adult rats. We added a 5% CO2 - challenge to analyze vasoreactivity in the same animals. Results from MRI were compared to histological correlates of angiogenesis. We found that CBF in the ischemic area recovered within one day and reached values significantly above contralateral thereafter. The extent of hyperperfusion changed over time, which was related to final infarct size: early (day 1) maximal hyperperfusion was associated with smaller lesions, whereas a later (day 4) maximum indicated large lesions. Furthermore, after initial vasoparalysis within the ischemic area, vasoreactivity on day 14 was above baseline in a fraction of animals, along with a higher density of blood vessels in the ischemic border zone. These data provide further evidence that late post-ischemic hyperperfusion is a sequel of ischemic damage in regions that are likely to undergo infarction. However, it is transient and its resolution coincides with re-gaining of vascular structure and function. |
| Databáze: | OpenAIRE |
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