Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
| Autor: | Peter Kiraly, Nicolas Kern, Mateusz P. Plesniak, Mathias Nilsson, David J. Procter, Gareth A. Morris, Ralph W. Adams |
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| Přispěvatelé: | University of Manchester [Manchester], Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
nuclear Overhauser effect
Materials science Proton natural products Nuclear Overhauser effect 010402 general chemistry 01 natural sciences Catalysis Spectral line 030218 nuclear medicine & medical imaging 03 medical and health sciences NMR spectroscopy 0302 clinical medicine Nuclear magnetic resonance [CHIM.ANAL]Chemical Sciences/Analytical chemistry Multiplet NMR Spectroscopy | Hot Paper 010405 organic chemistry Communication structure elucidation selectivity General Medicine General Chemistry Nuclear magnetic resonance spectroscopy Communications 0104 chemical sciences Excited state Proton NMR Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Angewandte Chemie International Edition Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (2), pp.666-669. ⟨10.1002/anie.202011642⟩ Angewandte Chemie (International Ed. in English) |
| ISSN: | 1433-7851 1521-3773 |
| DOI: | 10.1002/anie.202011642⟩ |
| Popis: | 2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation and unlock its real potential for many other experiments. Selective excitation of overlapped multiplets in a single scan broadens the applicability of 1D selective NMR experiments. |
| Databáze: | OpenAIRE |
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