Cellular senescence links aging and diabetes in cardiovascular disease
| Autor: | Andreas B. Gevaert, Katrien Lemmens, Hadis Shakeri, Guido R.Y. De Meyer, Vincent F.M. Segers |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Physiology Cellular senescence Disease Bioinformatics Cardiovascular Diseases -- etiology -- metabolism 03 medical and health sciences Physiology (medical) Diabetes mellitus cellular senescence diabetes medicine Diabetes Mellitus Animals Humans Risk factor Cellular Senescence Senescence-Associated Secretory Phenotype business.industry aging Aging -- metabolism Sciences bio-médicales et agricoles medicine.disease cardiovascular diseases 030104 developmental biology Diabetes Mellitus -- etiology -- metabolism Cardiovascular Diseases Concomitant Heart failure senescence-associated secretory phenotype Human medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | American journal of physiology: heart and circulatory physiology American journal of physiology. Heart and circulatory physiology, 315 (3 |
| ISSN: | 0363-6135 |
| Popis: | Aging is a powerful independent risk factor for cardiovascular diseases such as atherosclerosis and heart failure. Concomitant diabetes mellitus strongly reinforces this effect of aging on cardiovascular disease. Cellular senescence is a fundamental mechanism of aging and appears to play a crucial role in the onset and prognosis of cardiovascular disease in the context of both aging and diabetes. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. This senescence-associated secretory phenotype is a trigger of chronic inflammation, oxidative stress, and decreased nitric oxide bioavailability. A complex interplay between these three mechanisms results in age- and diabetes-associated cardiovascular damage. In this review, we summarize current knowledge on cellular senescence and its secretory phenotype, which might be the missing link between aging and diabetes contributing to cardiovascular disease. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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