| Autor: |
Toshiyuki Mio, Nobuya Ishii, Haruhiko Sato, Hiroshi Koyano, Hirosato Ebiike, Kiyomoto Ogasawara, Kiyoaki Sakata, Toshihiko Fujii, Yukako Tachibana, Yasuko Satoh, Masami Hasegawa, Hiromi Tanimura, Nukinori Akiyama, Kana Horiguchi-Takei, Takakazu Mizuno, Yoshito Nakanishi, Natsuki Hamanaka |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S1. YES1 gene is amplified and YES1 expression is related to poor prognosis in esophageal cancer and lung cancer in clinical. Supplementary Figure S2. YES1 gene amplification including the upregulation of YES1 expression. Supplementary Figure S3. Cell growth inhibition profile of various molecular targeted agents. Supplementary Figure S4. Antiproliferative activity of dasatinib against cancer cell lines expressing YES1-WT or YES1-GK. Supplementary Figure S5. The contribution of SFK other than YES1 in YES1-amplified cancer cell lines. Supplementary Figure S6. The antitumor activity of dasatinib against YES1-amplified xenograft tumor. Supplementary Figure S7. Dasatinib inhibited YAP1 downstream signal via YES1 kinase inhibition against YES1-amplified cancer cell. Supplementary Figure S8. YAP1 and DAPI staining in treatment with CH6953755. Supplementary Figure S9. YAP1 localization change in xenograft tumor tissue by CH6953755 treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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