Correlations between clinical and historical variables, and cerebral structural variables in people with mild intellectual disability and schizophrenia
| Autor: | Jonathan J.K. Best, E. C. Johnstone, T. L. Sanderson, David G. C. Owens, Gillian A. Doody |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Population Comorbidity Disease Hippocampus Arts and Humanities (miscellaneous) Neuroimaging Risk Factors Intellectual Disability Intellectual disability medicine Humans Family history Dominance Cerebral Psychiatry education Aged Psychiatric Status Rating Scales education.field_of_study Rehabilitation Brain Middle Aged Amygdala medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Neurology Schizophrenia Brain Damage Chronic Female Neurology (clinical) Psychology |
| Zdroj: | Journal of Intellectual Disability Research. 45:89-98 |
| ISSN: | 1365-2788 0964-2633 |
| DOI: | 10.1046/j.1365-2788.2001.00337.x |
| Popis: | The increased prevalence of schizophrenia in the population with mildly intellectual disability (ID) remains unexplained. The present study explores several possibilities by examining historical/clinical findings in relation to structural neuroimaging findings in three groups: (1) comorbid mild ID and schizophrenia; (2) schizophrenia alone; and (3) mild ID alone. Information about clinical and historical variables was obtained from 101 subjects (39 with comorbidity, 34 with schizophrenia and 28 with mild ID), out of whom 68 (23, 25 and 20, respectively) had had a cerebral magnetic resonance imaging (MRI) scan. Although a number of significant correlations exist between clinical variables and structural MRI abnormalities in all three groups, no clearly predictive inter- or between-group differences emerged. More striking was the finding that showed small amygdalo-hippocampal size to be associated with a history of central nervous system injury, especially meningitis. These findings provide support for the view that cognitive impairment and comorbid psychosis can result from a common cause, such as meningitis or obstetric complications, possibly interacting with other factors, such as family history. |
| Databáze: | OpenAIRE |
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