Effect of Metoclopramide, Bethanechol, and Loperamide on Gastric Residence Time, Gastric Emptying, and Mouth-to-Cecum Transit Time
| Autor: | William D. Heizer, Judy C. Bryson, George E. Dukes, M. Gray Kirby, J. Robert Powell |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Loperamide Adolescent Metoclopramide Transit time Bethanechol Residence time (fluid dynamics) Cecum Piperidines Bethanechol Compounds Statistical significance medicine Humans Pharmacology (medical) Gastrointestinal Transit Gastric emptying business.industry medicine.anatomical_structure Gastric Emptying Anesthesia Gastrointestinal Motility business medicine.drug |
| Zdroj: | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 9:226-231 |
| ISSN: | 0277-0008 |
| DOI: | 10.1002/j.1875-9114.1989.tb04130.x |
| Popis: | The effects of metoclopramide, bethanechol, and loperamide on the gastric residence time (GRT), gastric emptying (GE), and mouth-to-cecum transit time (MCTT) of a solution were investigated in three separate studies of five healthy male volunteers each. Metoclopramide in doses of 5, 10, and 15 mg prolonged GRT by 33, 88, and 162%, respectively, almost reaching statistical significance (p 0.058). A relationship was observed between GRT prolongation, and metoclopramide area under the plasma-time curve (p 0.01) and metoclopramide observed time to maximum concentration (p 0.01). Metoclopramide had an inconsistent effect on MCTT. Bethanechol 50 mg prolonged GRT by 64% (p 0.031) and had no effect on MCTT. Loperamide at doses of 2 and 8 mg prolonged GRT by 18 and 115% (p 0.043) and MCTT by 30 and 130% (p 0.0001), respectively. None of these motility-altering agents affected GE. |
| Databáze: | OpenAIRE |
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