Combination of Osthole and Cisplatin Against Rhabdomyosarcoma TE671 Cells Yielded Additive Pharmacologic Interaction by Means of Isobolographic Analysis
| Autor: | Jarogniew J. Łuszczki, Marta Halasa, Krzysztof Polberg, Krystyna Skalicka-Woźniak, Jolanta Smok-Kalwat, Małgorzata Guz, Agata Jarząb, Andrzej Stepulak |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Antineoplastic Agents Pharmacology 03 medical and health sciences chemistry.chemical_compound Coumarins Cell Line Tumor Rhabdomyosarcoma medicine Humans neoplasms Cell Proliferation Cisplatin Cell growth Drug Synergism General Medicine Coumarin medicine.disease Chemotherapy regimen female genital diseases and pregnancy complications 030104 developmental biology Anticonvulsant Oncology chemistry Cell culture Combined therapy medicine.drug |
| Zdroj: | Anticancer research. 38(1) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM Osthole is a simple coumarin that has been found to have anticancer, anti-inflammatory, antiviral, anticoagulant, anticonvulsant and antiallergic activities. The aim of this study was to analyze the combined anti-proliferative effect of cisplatin (CDDP) and osthole on a rhabdomyosarcoma cell line, and assess the pharmacology of drug-drug interaction between these drugs using isobolographic analysis. MATERIALS AND METHODS The anticancer actions of osthole in combination with CDDP were evaluated using the tetrazolium dye-based MTT cell proliferation assay. RESULTS Osthole and CDDP applied together augmented their anti-cancer activities and yielded an additive type of pharmacologic interaction by means of isobolographic analysis. CONCLUSION Combined therapy using osthole and cisplatin could be suggested as a potential chemotherapy regimen against rhabdomyosarcoma. |
| Databáze: | OpenAIRE |
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