Application of RNA interference in treating human diseases
| Autor: | Sanaz Samad Poor, S. Abdolhamid Angaji, Samin Panahi, Sara Sadate Hedayati, Safoura Madani, Reihane Hosein Poor |
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| Rok vydání: | 2011 |
| Předmět: |
Genetics
RNA-induced silencing complex fungi HIV Infections Neurodegenerative Diseases Argonaute Biology Hepatitis C RNA silencing Cerebrovascular Disorders Metabolic Diseases Transcription (biology) RNA interference Cardiovascular Diseases Virus Diseases Neoplasms Viruses Gene silencing Humans RNA Interference Gene Silencing Psychological repression Gene |
| Zdroj: | Journal of genetics. 89(4) |
| ISSN: | 0973-7731 |
| Popis: | Gene silencing can occur either through repression of transcription, termed transcriptional gene silencing (TGS), or through translation repression andmRNA degradation, termed posttranscriptional gene silencing (PTGS). PTGS results from sequence-specific mRNA degradation in the cytoplasm without dramatic changes in transcription of corresponding gene in nucleus. Both TGS and PTGS are used to regulate endogenous genes. Interestingly, mechanisms for gene silencing also protect the genome from transposons and viruses. In this paper, we first review RNAi mechanism and then focus on some of its applications in biomedical research such as treatment for HIV, viral hepatitis, cardiovascular and cerebrovascular diseases, metabolic disease, neurodegenerative disorders and cancer. |
| Databáze: | OpenAIRE |
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